By Sam | First published September 8, 2025 | Last modified September 9, 2025 Androgenetic alopecia is a common condition affecting a significant proportion of transfeminine people at onset of hormonal transition. Although several studies ha…
By Mitzi | First published January 30, 2022 | Last modified January 31, 2022 Puberty blockers are medications used to pause puberty in both cisgender and transgender youth. For the latter, significant evidence suggests that they improve wel…
By Aly | First published July 16, 2021 | Last modified April 12, 2023 Links to go straight to the simulator: Original Simulator and Advanced Simulator Estradiol is frequently used in injectable form in transfeminine hormone therapy. Injecta…
By Aly | First published July 16, 2021 | Last modified May 8, 2025 Injectable estradiol preparations such as estradiol valerate and estradiol cypionate in oil are frequently used as estrogens in transfeminine hormone therapy. However, there…
By Sam | First published June 11, 2021 | Last modified August 14, 2025 Sublingually-administered estradiol is an alternative route of administration to oral estradiol that has been used by a limited number of gender-affirming care providers…
By Aly | First published November 20, 2020 | Last modified November 17, 2024 This article is a collection of clinical practice guidelines throughout the world with information on transfeminine hormone therapy. Examples of these clinical gui…
By Aly | First published October 25, 2020 | Last modified December 18, 2025 A claim has been originated by some in the online transgender community that the antiandrogen spironolactone increases visceral fat in transfeminine people and that…
By Aly | First published October 20, 2020 | Last modified March 28, 2023 Estrogens increase coagulation by activating estrogen receptors in the liver and thereby modulating the production of a variety of circulating coagulation factors. Wit…
By Aly | First published July 10, 2020 | Last modified March 25, 2023 Sex hormones such as testosterone and estradiol bind to blood proteins like albumin and SHBG. This limits their biological activity by reducing their free fractions. Andr…
By Aly | First published July 8, 2020 | Last modified March 14, 2023 This article is a supplement to the article here. It was originally just for calculation of free sex hormone levels but I decided to add some other content to it as well.
By Lain | First published May 9, 2020 | Last modified October 5, 2020 The studies here do not show significant hip bone growth in adult transfeminine individuals under hormone therapy. They do show, however significant feminizing body shape…
By Aly | First published April 29, 2020 | Last modified April 7, 2023 This is a collection of published data on hormone levels throughout normal puberty in cisgender girls. Levels of estrogens (estradiol and estrone), progesterone, and andr…