INTRODUCTION: Poor adherence to oral antipsychotic (OAP) therapy is a major driver of relapse in patients with schizophrenia, as only 50% or fewer patients are adherent to OAP during the first year, leading to suboptimal clinical outcomes a…
INTRODUCTION: Septic shock is frequently complicated by tachyarrhythmias, which are associated with a poorer prognosis and increased intensive care unit stays. Landiolol, an ultra-short acting β-blocker, is effective in controlling heart ra…
BACKGROUND: Moderate-to-severe Crohn’s disease (CD) significantly impacts patients and the healthcare system. Timely initiation of biologic therapy is crucial for clinical outcomes and economic efficiency. In Italy, however, many patients e…
AIM: This analysis aimed to assess the annual International Unit (IU) consumption and costs of prophylaxis therapies with extended half-life recombinant FVIII (EHL-rFVIII), targeting a traditional trough level of 1% and the higher levels of…
OBJECTIVES: To estimate the epidemiological distribution and economic impact of gastric and gastroesophageal junction neoplasms in Italy. METHODS: Retrospective transversal and longitudinal analyses were conducted using the Italian Hospital…
OBJECTIVE: A cost-per-responder model was developed to compare the pharmacoeconomic value of dupilumab and tralokinumab, in combination with topical corticosteroids (TCS), for treating atopic dermatitis (AD) in Italy.METHODS: An indirect tr…
OBJECTIVES: This research aimed to provide updated epidemiological estimates of multiple myeloma (MM) in Italy and to characterize the clinical journey, treatment patterns, and economic burden focusing specifically on the subset of patients…
INTRODUCTION: Grade 4 glioma is among the most aggressive forms of central nervous system tumors, posing a substantial clinical, humanistic, and economic burden on patients, caregivers, and society. Recent clinical and observational studies…
BACKGROUND: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), is a significant health problem with especially increased prevalence, morbidity and mortality in patients with cancer. This stu…
OBJECTIVES: The aim of this study was to evaluate the cost‑effectiveness of apixaban in the prevention of thromboembolic events in patients with non‑valvular atrial fibrillation (NVAF) relatively to standard of care (warfarin or aspirin) fr…
OBJECTIVE: To simulate haemophilia A (HA) real-life management and compare the cost of different treatment strategies, both with plasma-derived and recombinant factor VIII (pdFVIII and rFVIII, respectively), from the perspective of the Ital…
OBJECTIVE: To assess the economic impact of two preventive strategies against respiratory syncytial virus (RSV) infection in Italian newborns: universal administration of nirsevimab versus a complementary approach combining maternal RSVpreF…