MSTPublications July 2026

Buobe IA context · why it matters

BCL6 loss prevents diabetes despite anti-insulin B cells — More selective therapies targeting CD4+ T cells might better control type 1 diabetes.
Anti-insulin B cells reside in extrafollicular niches — Targeting these specific niches could be a novel approach to treat or prevent the disease.

Published by

medschool.vanderbilt.edu

on •1 min read

BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes. Clark LM, McAninch JC, McNitt DH, Padgett ML, Jenkins TW, Bass LE, Nichols CM, Rathmell JC, Bonami RH.

type 1 diabetes bcl6 t cells immunotherapy

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